Show HN: CUDA, Shmuda: Fold Proteins on a MacBook
latentspacecraft.comAlphafold3 used to be fodder for HPC clusters; now I've got a port running smoothly on Apple Silicon. If you have an M-series Mac (~2023-present), you can generate protein structures from sequences in minutes. Give it a try!
GitHub repo: https://github.com/latent-spacecraft/openfold-3-mlx
Curious to try, thanks for putting this out.
What did you find to be the most surprising challenge in this project?
^How convoluted MSA and template handling is under the hood in openfold. I’m working on a simple offline replacement next. Compared to that, the attention functions were fairly easy to convert to MLX ops.